Formulation machine

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  "buyer": {
    "id": "GB-COH-00559784",
    "name": "THE PIRBRIGHT INSTITUTE"
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      "dateSigned": "2025-03-19T00:00:00Z",
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  "ocid": "ocds-h6vhtk-054e66",
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        "streetAddress": "Pirbright Laboratory Ash Road"
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      "contactPoint": {
        "email": "OrdersUK@cytiva.com"
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    "description": "As a first step towards evaluating the use of RNA vaccines for livestock, the Centre for Veterinary Vaccine Innovation and Manufacturing (CVIM) collaborated ) to carry out a proof-of-principle study.   The success of this work has led to the continued evaluation by CVIM of RNA-based vaccines for livestock.\nTo facilitate the continued evaluation of RNA-based vaccines for livestock CVIM needs to develop the capacity to produce formulated mRNA vaccine candidates at a suitable scale to carry out in vivo immunogenicity studies. A machine to encapsidate RNA is required to produce formulated mRNA vaccines.\nA suitable formulation machine needs to: \n\u2022\tBe compact (small footprint) to enable its location in existing CVIM R\u0026D facilities.\n\u2022\tEnable application of Good Laboratory Practice\n\u2022\tHave seamless scalability to enable higher levels of production at good manufacturing practice (GMP, to meet regulatory compliance).\n\u2022\tBe capable of encapsidating mRNA of differing complexity using different LNP formulations.\n\u2022\tBe user-friendly (reduced training requirements and user error). \n\u2022\tProvide a protective environment for products (low bioburden).\n\u2022\tProduce suitable volumes (capacity to support in vivo studies).\n\u2022\tCompatible with existing and collaborator\u0027s equipment to enable the transfer of reagents and methods. Specifically, the encapsidation machine needs to be compatible to our recently purchased Ntensify Mini (RNA producing machine).",
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    "status": "complete",
    "title": "Formulation machine"
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