Buyer Name: Centre for Process Innovation Limited
Buyer Address: Wilton Centre, Redcar, UK, TS10 4RF
Contact Name: E-Tendering
Contact Email: e-tendering@uk-cpi.com
Contact Telephone: +44 1642455340
Buyer Name: Centre for Process Innovation Limited
Buyer Address: Wilton Centre, Redcar, UK, TS10 4RF
Contact Name: E-Tendering
Contact Email: e-tendering@uk-cpi.com
Contact Telephone: +44 1642455340
You are invited to submit a tender for the following requirements; analytical services for multiple modalities drug substances and drug products required for early phase clinical trials. This tender is to cover the analytical services required for release analysis of drug substance (DS) and drug product (DP).
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External Link: https://www.publiccontractsscotland.gov.uk/search/show/search_view.aspx?ID=MAY530845
Link Title: Framework for QC Analytical Testing Requirements
Link Description: You are invited to submit a tender for the following requirements; analytical services for multiple modalities drug substances and drug products required for early phase clinical trials. This tender is to cover the analytical services required for release analysis of drug substance (DS) and drug product (DP).
Lot Title: RNA Therapeutic/Vaccines
Lot Description: Our facility in Darlington currently manufactures RNA-LNP vaccines and therapeutics for Phase 1 clinical trials. Both the drug substance and drug product are presented as liquid formulations. The requirements for RNA-LNP analysis include: - Method development, verification and Phase appropriate validation (as required) - Integrity analysis for RNA In-process samples, RNA-LNP drug substance and drug product (release and stability analysis) - Process impurity testing for RNA-LNP drug substance and drug product
Lot 2 Status: complete
Lot 2 Has Options: No
Lot 2 Award Criterion (quality): GMP Questionnaire
Lot Title: Recombinant Protein Therapeutics
Lot Description: Our facility in Darlington will, in the future, manufacture Recombinant protein vaccines and therapeutics produced in Microbial cell lines, for Phase 1 clinical trials. Both the drug substance and drug product are presented as liquid formulations. The requirements for Recombinant Protein analysis include: - Method development, verification and Phase appropriate validation (as required) - Integrity analysis for Recombinant Protein drug substance and drug product (release and stability analysis) - Process impurity testing for Recombinant Protein drug substance and drug product
Lot 3 Status: complete
Lot 3 Has Options: No
Lot 3 Award Criterion (quality): GMP Questionnaire
Lot Title: Process and Product Microbiology (Teesside Area)
Lot Description: Our facility in Darlington will require Microbiology testing to support the RNA-LNP and Recombinant Protein GMP manufacture. The following analysis is required, all under Ph.Eur: - Endotoxin (Buffers) - Endotoxin (Process product Protein) - Endotoxin (Process product RNA and RNA-LNP) - Bioburden (Buffers) - Bioburden (Process product Protein) - Bioburden (Process product RNA and RNA-LNP)
Lot 4 Status: complete
Lot 4 Has Options: No
Lot 4 Award Criterion (quality): GMP Questionnaire
Lot Title: Process and Product Microbiology (Glasgow Area)
Lot Description: Our facility in Glasgow will require Microbiology testing to support the GMP manufacturing of oligonucleotide therapies. The following analysis is required, all under Ph.Eur: - Endotoxin (Process product oligonucleotide) - Bioburden (Process product oligonucleotide)
Lot 5 Status: complete
Lot 5 Has Options: No
Lot 5 Award Criterion (quality): GMP Questionnaire
Lot Title: Oligonucleotides
Lot Description: The facility at MMIC will manufacture both single and double stranded novel oligonucleotides for early phase clinical trials. The drug substance (API) may be a lyophilised powder or solution API and the finished drug product may be a solid or liquid formulation. The requirements for oligonucleotides analysis include: - Chemical analysis for oligonucleotide drug substance and drug product (release and stability analysis) - Method development, verification and phase appropriate validation (as required)
Lot 6 Status: complete
Lot 6 Has Options: No
Lot 6 Award Criterion (quality): GMP Questionnaire
Lot Title: Water Testing (Glasgow Area)
Lot Description: The MMIC facility near Glasgow will require microbiological testing of water samples in accordance with Ph. Eur. [0169]. The following analysis techniques are required and have been included in pricing schedule for comparison: -Microbiological monitoring (Ph. Eur.) -Bacterial endotoxin testing (Ph. Eur.)
Lot 1 Status: complete
Lot 1 Has Options: No
Lot 1 Award Criterion (quality): GMP Questionnaire
Document Title: Framework for QC Analytical Testing Requirements
Document Description: You are invited to submit a tender for the following requirements; analytical services for multiple modalities drug substances and drug products required for early phase clinical trials. This tender is to cover the analytical services required for release analysis of drug substance (DS) and drug product (DP).
Contract Title: Water Testing (Glasgow Area)
Contract Title: RNA Therapeutic/Vaccines
Contract Title: Recombinant Protein Therapeutics
Contract Title: Process and Product Microbiology (Teesside Area)
Contract Title: Process and Product Microbiology (Glasgow Area)
Contract Title: Oligonucleotides
Award Title: Water Testing (Glasgow Area)
Award Title: RNA Therapeutic/Vaccines
Award Title: Recombinant Protein Therapeutics
Award Title: Process and Product Microbiology (Teesside Area)
Award Title: Process and Product Microbiology (Glasgow Area)
Award Title: Oligonucleotides
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"type": "quality"
},
{
"description": "30",
"type": "price"
}
]
},
"description": "The MMIC facility near Glasgow will require microbiological testing of water samples in accordance with Ph. Eur. [0169]. The following analysis techniques are required and have been included in pricing schedule for comparison:\r\n -Microbiological monitoring (Ph. Eur.)\r\n -Bacterial endotoxin testing (Ph. Eur.)",
"hasOptions": false,
"id": "1",
"status": "complete",
"title": "Water Testing (Glasgow Area)"
}
],
"mainProcurementCategory": "services",
"procurementMethod": "open",
"procurementMethodDetails": "Open procedure",
"status": "complete",
"title": "Framework for QC Analytical Testing Requirements"
}
}